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China sets its sights on life sciences
<p>Governments and public health policy makers around the world have long struggled with providing access to affordable health care while at the same time promoting life science innovation. China is no different. Its pharmaceutical landscape today has been shaped by the government’s quest to achieve universal health care through a national health care system. And the evolving industry landscape and the government’s pro-innovation policies are driving indigenous innovation in its life science industry.</p> <p>China is a market too large to be ignored—this has long been a saying among those considering doing business in the country. But increasingly, multinational corporations see China as a hub of nascent innovation in life sciences, and have been setting up research and development (R&amp;D) centers for new drug candidates that target global markets. To be sure, there are some challenges. This month’s Asia Insight explores China’s path in this arena.<br /> China’s Pharmaceutical Landscape<br /> It’s hard to overlook China’s pharmaceutical market given its size and growth rate. Public and private expenditure on pharmaceuticals totaled US$76 billion in 2014, and this is expected to reach US$315 billion at a compound annual growth rate of 23% by 2020, which would make it the second-largest pharmaceutical market in the world after the U.S. Both China’s central and local governments have played an integral role in shaping the current landscape of the fragmented pharmaceutical market. The focus on affordable health care has led to the prevalence of generic drugs, which have taken over 80% of the market. Domestic and multinational pharmaceutical companies have pursued very different strategies. Multinational companies have focused on patented drugs and some drug originators that enjoy preferential pricing premiums under the existing drug pricing system. Domestic companies, on the other hand, have not invested much in R&amp;D, and have focused predominantly on making generics.</p> <p>The most successful domestic companies have focused on branded generics, which are generic drugs marketed under a company’s proprietary brand name. This has been a profitable approach due to the limited scope of R&amp;D investment and price premiums. But generic drug makers often have to participate in government tendering, and face intense competition and government price cuts. They rely on their knowledge of tiered markets and extensive distribution networks to achieve economies of scale.</p> <p>Essential Medicines<br /> Essential medicines are defined by the World Health Organization as those that satisfy the priority health care needs of the population. In 2009, China’s Ministry of Health published its first list of essential drugs, which are subsidized by local and central governments. China’s fragmented domestic pharmaceutical industry includes approximately 5,000 drug manufacturers, with the top 100 drug makers comprising just one-third of the market. Going forward, the regulatory environment is increasingly shifting against sub-scale inefficient generic players due to the more intense pricing pressure from the expanding Essential Drug List (EDL) and higher compliance costs.</p> <p>The EDL was initially designed to make medicine more affordable for low income patients, and was implemented at grassroots, mostly rural, facilities. In 2013, the government expanded the coverage of EDL to larger and better-equipped hospitals mainly located in urban areas. It required EDL drugs to reach 40% of Class 2 hospitals and 25% of Class 3 hospitals in revenues to ensure better access to affordable dr</p>
China deserves more credit than blame
<p>The visit to the US later this month by China’s President Xi Jinping comes at a politically sensitive time, with volatility in China’s markets—widely attributed to the effect of policy decisions—rippling globally. In our view, however, China deserves more credit than blame for its recent actions.</p> <p>As China attempts to make the transition to a more open economy, two things are virtually inevitable: market volatility and extremely difficult policy decisions, many of which need to be taken in the heat of the moment.</p> <p>A case in point is the government intervention that followed the initial correction in the A shares market in July. This was widely interpreted outside China as a panicky reaction. But China’s share market is largely retail driven, and the need to maintain social harmony is of paramount importance to a single-party state. In light of this, the government’s response makes sense.</p> <p>But what do we make of China’s decision to devalue its currency last month, just weeks before President Xi was due to make his first official visit to the US? The move was widely characterized as an attempt by China to shore up its sputtering export performance. Given that US politicians have for years accused China of keeping the renminbi artificially low, and that bilateral trade will be a key talking point when President Xi meets President Obama, surely the timing of the move was, at the very least, politically inept?</p> <p>We don’t think so. In our view, the currency adjustment provides another example of how easy it is to misinterpret China’s policy actions.</p> <p>Devaluation? Or a Step in the Right Direction?</p> <p>Describing the move as a competitive devaluation ignores a number of facts—such as that China’s exports, while challenged, have largely performed better than those of its regional competitors. For this reason alone, it’s hard to see why a competitive devaluation would be necessary.</p> <p>Also, China’s trade balance is positive (imports are falling faster than exports) and the country has an embarrassingly large trade surplus. Devaluation would simply exacerbate these issues, and do so at precisely the wrong political moment.</p> <p>Far more plausible, from our point of view, is the explanation by the People’s Bank of China that the adjustment was intended to close an unusually large gap between the currency fix and the spot price. This made sense given that the central bank lowered the fix by just 1.9% and stepped into the market to support the currency when it came under pressure as the devaluation story took hold.</p> <p>It also made sense as a reflection of government policy, which is to modernize and diversify the economy using private capital from inside and outside the country. To do this, China needs a more market-oriented currency—hence the move to align the fix more closely with the spot price.</p> <p>Good News, Mr. President</p> <p>Our research suggests that China is in fact less focused on its currency than on the need to deliver liquidity into the right parts of the domestic economy so that consumption becomes more of a growth driver alongside the traditional engines of exports and investment.</p> <p>President Xi can tell President Obama some good news in this respect: recent data show a convergence in fixed-asset investment and retail sales trends, with the former falling and the latter holding steady (Display). While the figures are not particularly exciting in themselves, they suggest that China’s economic rebalancing is under way.</p>
Weekend Scan: China's central bank chief says worst is over for markets
<p>The migrant crisis continues apace even with Germany and Austria accepting desperate refugees from Syria. Pope Francis  "called on 'every' parish, religious community, monastery and sanctuary to take in one refu­gee family — an appeal that, if honored, would offer shelter to tens of thousands." In the U.S., millions of Americans are bidding a sad adieu to summer over Labor Day weekend. Monday, markets are closed.</p> <p>Here is what else you need to know:</p> <p>PBOC chief says the worst is over. Zhou Xiaochuan said the stock market rout is over and the yuan is heading into a steady state after the surprise devalutation last month.  Zhou made the remarked in Ankara during a two-day G20 meeting.  Surprisingly, world leaders struck an optimistic tone despite data revealing just how how much China's growth is slowing.  For the moment, all is good. The week poses challenges with a slew of data. The fun begins Monday morning when China releades foreign exchange reserves data for August.</p> <p>Asia markets mostly lower. Hong Kong, the Nikkei, Korean and Chinese indices were mostly lower -- 1%-2%. Australia bucked the trend, edging 0.4% as dod the CSI 300 futures market, which gained 0.72%.</p> <p>Pope is nervous about his first ever visit to the U.S., says Cardinal Dolan. The head of the Catholic Church has favored visiting the poor to the rich. Pope Francis has been critical in the past of the political and economic power in the U.S.  New York Times (paywall)</p> <p>Fiat Chrysler, GM merger on “high priority.” Fiat Chrysler CEO Sergio Marchionne isn't taking "no"lying down. GM rebugged Marchionne in a merger bid, but he's at it again because he says the move would “be the best possible strategic alternative for us and for them.” Reuters</p> <p>Falling oil prices hit Saudi Arabia. With crude oil prices practically cut in half, the world’s largest oil producer is currently working on slashing unnecessary expenses and delaying state projects. Which is ironic because they were the ones who opened up the taps to begin with. They have, however, built reserves and decreased public debt to near-zero levels. BBC</p> <p>Nissan to repeat airbag recall. Federal regulators are worried that Nissan’s recall last year of almost one million vehicles did not correct a malfunction of the passenger airbag, meaning the automaker might have to recall the vehicles again. The New York Times (paywall)</p> <p>Euro founder fears a creation of an EU superstate. Almost everyone agrees that there’s just no way a monetary union can survive without a corresponding fiscal union. Well, Professor Otmar Issing, the chief architect of the European monetary union, fears that next step would be “dangerous,” and that an undemocratic political union may be in the works too. The Telegraph<br /> You wouldn’t believe this…<br /> “Resting bitch face” apparently makes women better communicators. While women with cheerful, emphatic facial expressions and body language receive nothing but good vibes, women with “RBF” apparently have to work harder toget their point across – which suppos</p>
Daily Scan: Mainland shares tumble; China FX reserves post largest monthly drop
<p>Updated throughout the day</p> <p>September 9</p> <p>Good evening everyone. PBOC Governor Zhou Xiaochuan may have said that the multi-trillion dollar “correction” is “almost done,” but that doesn’t mean that mainland stocks didn’t want to do some correcting of their own. The SHCOMP lost all of its gains today, finishing the session down 2.52%, while Shenzhen retraced most of its earlier 3.7% rally to close up 0.2%. Even the nation’s forex reserves did some correcting, falling $94 billion to $3.56 trillion to notch up its largest monthly drop on record.</p> <p>Here’s how the rest of Asia is faring:</p> <p> Nikkei 225: +0.38%<br /> Hang Seng Index: -1.23%<br /> Straits Times Index: -0.4%</p> <p>The European market seems to be doing much better though; the FTSE 100 climbed 1.3% to 6,119, the DAX jumped 1.2% to 10,161, while the CAC spiked 1.2% to 4,580. Here’s what else you need to know:</p> <p>Chinese GDP revised lower to 7.3%. In a surprise move, China’s National Bureau of Statistics revised its annual economic growth rate for 2014 from 7.4% to 7.3%, largely thanks to a slowdown in the services industry. The primary (agriculture) and secondary (manufacturing &amp; construction) sectors however still looks pretty good. Reuters</p> <p>Toshiba posts $318m annual loss. Reeling from its recent accounting scandal, the Japanese conglomerate has reported a net loss of 37.8 billion yen ($318 million) for the past financial year, citing asset impairment changes and other losses. The firm had at one time expected a 120 billion yen profit. Nikkei</p> <p>Experts reject official account of Mexico student deaths. An international committee reviewing the case of 43 missing college students in Mexico said there was no evidence to support the official line that the students were executed by a drug gang, fueling suspicion of police involvement. New York Times</p> <p>Fiat Chrysler, GM merger on “high priority.” Fiat Chrysler CEO Sergio Marchionne had some pretty interesting stuff to say over the weekend.  Despite being rebuffed earlier this year by the U.S.’ largest carmaker, Marchionne said that a merger between GM and Fiat Chrysler Automobiles remains a “high priority for FCA,” believing that the move would “be the best possible strategic alternative for us and for them.” Reuters</p> <p>Falling oil prices hit Saudi Arabia. With crude oil prices practically cut in half, the world’s largest oil producer is currently working on slashing unnecessary expenses and delaying state projects. Which is ironic because they were the ones who opened up the taps to begin with. They have however, built reserves and decreased public debt to near-zero levels. BBC</p> <p> Nissan to repeat airbag recall. Federal regulators are worried that Nissan’s recall last year of almost one million vehicles did not correct a malfunction of the passenger airbag, meaning the automaker might have to recall the vehicles again. </p>
Serena Williams gets no respect when it comes to endorsement. Here's why.
<p>Serena Williams stands on the cusp of winning all four major tennis tournaments in one year, a feat that has been seen just five times, the last time in 1988. Despite her prowess on the court, Williams makes much less money than other tennis stars.</p> <p>On Forbes's list of highest paid athletes Williams ranks 47th, reports The Atlantic. Of the seven tennis players on the Forbes list, Williams is last for endorsement deals with just $13 million annually. Williams is poised to win her 22nd Grand Slam title this year, and has dominated American sports, let alone women's tennis. Roger Federer, the male tennis counterpart to Williams, will earn almost $58 million in endorsements this year. Even Maria Sharapova, no where near able to touch Williams' skill, will make $10 million more than Williams. So what gives?</p> <p>For starters Williams isn't male. Despite what one could assume, Federer falls short of Williams' 21 Grand Slams, holding only 17. Federer has spent 302 weeks ranked number one. Williams has been number one for 250 weeks, but she's on the road to surpass Federer soon. And as for win-loss rations, Federer has about 4.4 wins per loss. Williams has 6. It's not like Federer or his male counterparts are bringing more viewers than Williams either. The women's finals in the U.S. Open have surpassed the men's for the last two years. This year, the women's final of the U.S. Open sold out before the men's.</p> <p>Sorry "experts," men really aren't more marketable for athletics either, even though marketers love targeting young men. Women control $29 trillion buying power in across the globe, and make 64% of household purchasing decisions. Sketchers and Nike have both picked up on it, steering their marketing to women.</p> <p>Williams' other problem, apparently, is that she's black and muscular. Thin, blonde Sharapova makes more than Williams, although she's not as strong of a player. Williams has been attacked before for looking too "manly," and not fitting the stereotypical feminine sexy that Sharapova does.</p> <p>At least Williams' doesn't let her under-appreciated value keep her down. She recently launched the "Greatness Collection" with Nike, and is ready to slay anyone standing between her and another Grand Slam.<br /> Photo: Marianne Bevis</p>
What makes a financial center? In one word: Flexibility
<p>I have been mulling a question, prompted by a silly article in the Financial Times. The piece contended that Barclays’ exit from much of investment banking was the end of prominence for London as a financial center. Ridiculous.</p> <p>This got me wondering: What does make a financial center. Why has my town, New York, been a financial center since the 18th century? Why has London been a financial center since long before that? Why were Amsterdam and Venice financial centers for a few centuries but are no more? Will Frankfurt, now the home of the ECB and Europe’s bank regulator, become a real financial center?</p> <p>There are so many tempting issues to explore. Please do not be too critical if I leave out your pet theory.</p> <p>In my opinion, people are what make a financial center. In the U.S., people who want to climb the letter of success head for NYC. People from all over the world who want to get ahead head for NYC. They have done so for a couple of centuries. Therefore NYC has a deeper talent pool that is more motivated than anywhere else. That deeper and more motivated talent pool also creates a place that such people like to live. It has restaurants, theaters, museums, a yoga studio or gym on every corner (it seems)—and high prices that only the successful can afford. If NYC ceases to be a magnet for people that want to get ahead, it will cease to be the world’s financial center. Taxes can be high—but there would be a limit. (Washington also has become a magnet, but for a different type of people.)</p> <p>London has similar advantages. Like NYC, it is exciting, international, intellectually stimulating. That is the source of London’s allure. If London makes living there unattractive, such as by taxing high earners too much, it will wither.</p> <p>Regulation also may play a role. But except at the extremes, clever people adapt to financial regulation. An August 19 comment in the FT by</p> <p>John Authers, a top Financial Times writer, recently cited studies showing that from 2008 to 2013, NYC increased its investment management market share from 12.6% of global assets to 20%. The studies attribute the growth to higher regulatory costs. You read that correctly. Those costs have meant that size has become more important to profitability. The cost of compliance has increased; therefore once the mechanisms are in place, they can cover whatever amount of assets. Maybe so, but to explain New York’s ability to benefit from that, I think we need to look again at talent and incentives.</p> <p>Will Frankfurt become the equal of London or New York? I think not. Flexibility is the key characteristic of successful people in New York and London. That is not yet true in Frankfurt and seems unlikely to be true in the near future. Just contrast the head of the Bundesbank with the Governor of the Bank of England or the Chair of the Fed or compare the German finance minister with a U.S. or British equivalent. I do not see the world’s go-getters going to Frankfurt to get.</p> <p>So what happened to Venice and Amsterdam? Venice and Amsterdam were financial centers because that is where the ships literally came in. Their financial basis was the world trade that their harbors made possible. When communications no longer required that finance and trade be in the same place, their financial prominence withered. Both still are wonderful cities, but they do not attract the world’s go-getters.</p> <p>Venice, Amsterdam, London and New York all have attracted, in their financial heydays, artists from all over the world. Maybe the arttists follow the money, like everyone else.</p> <p>Probably I am preju</p>
Putin wants to chummy up with China
<p>With its economy a mess, and its relations with its Western neighbors in tatters, Russia is in dire need of new friends. So, its leader - Vladimir Putin - is looking east to China.</p> <p>According to Reuters, Putin was at the Eastern Economic Forum in Vladivostok  earlier this week trying the woo Asian investors in a bid to drum up cash for Russia's neglected Far East region. </p> <p>“The possibilities in region,” Putin told Asian investors, “are enormous”. The Russian leader was touting the region - packed with natural resources, forestry and fish stocks - to delegates from Japan, South Korea, and, most importantly, China. </p> <p>Its Putin’s hope that Russia’s Asian friends will help turn his country’s Far East - which takes of a third of its landmass - into a "profitable business center". </p> <p>China is already throwing quite a bit of love Russia's way. Data from Rhodium, a China-focused research group, shows that China's direct investment into Russia totaled about $8.4 billion in 2014, up 10% from 2013. That’s almost half of the $18 billion China invested in the whole of Europe for the same period. </p> <p>With its economy buffeted by cheap oil and western sanctions, resulting from its conflict in Ukraine, Russia really needs its Asian allies. But then again, anyone with even with a passing interest in the global economic affairs will know that China is having a few money problems of its own right now.</p> <p>Photo: Donkey Hotey via Flickr</p>
Internet entrepreneur sells LA home
<p>Internet entrepreneur Jason Calacanis is leaving Los Angeles for San Francisco, and he's sold his home for $2.92 million.</p> <p>Calacanis, who has invested in Uber and Tumblr, was splitting his time between San Francisco and L.A. before August, reports Business Insider. He sold his L.A. home after having it on the market for almost a year, and was most recently listed for $2.998 million in July.</p> <p>The L.A. home has four bedrooms, a bright sun room, and a large swimming pool. The 1940's house resides in the high end Brentwood neighborhood. A separate pool house can provide extra space for guests.<br /> Photo:  Joi Ito</p>
ETFs may wobble, but can they 'flash crash'?
<p>Wobbly markets and international turmoil can get the best of even a seasoned investor. Take a look at what happened in the world of ETFs. When the Dow Jones Industrials plunged 10% on Black Monday, some ETFs went all haywire. The much-loved vehicle for Main Street suddenly stopped making sense.</p> <p>Kim Arthur, of Main Management, told ETF.com that the August 24 mayhem was  reminiscent of the May 2010 flash crash.</p> <p>&nbsp;</p> <p>Just to recall what happened: In the early trading hours, ETFs suffered a massive sell-off, with some funds seeing close to 50% losses. The iShares Select Divident fund was down 36%. And the Guggenheim S&amp;P 500 Equal Weight dropped 42%. Skittish investors sold the funds at huge discounts, only to see the security prices bounce back in minutes. Some investors were stalled for up to 20 minutes trying to log into their accounts, creating pent-up sell stops that slammed the market.</p> <p>Arthur says players aren't playing close enough attention to trade executions and keeping realistic bid/ask spreads.<br /> “I had thought, along with that flash crash in 2010, [regulators] told market makers they had to have some reasonable tolerance within your bid and your offers; otherwise, you cannot be making a market. You have to get out of the way,” Arthur said. “It seems like we saw that again [August 24].”<br /> Not so, says Ed Rosenberg, head of ETF Capital Market and Analytics for FlexShares. You can't compare the original "flash crash" of 2010 to a quick downturn in ETFs, he argues.  “Its almost impossible for the ETFs to crash on their own,” says Rosenberg. ETFs are tied so closely to the underlying securities that there needs to be serious price dislocation from securities for that to happen. Price dislocations do happen, but they self correct within seconds. "Those last so short it's unbelievable," says Rosenberg.</p> <p>The market did exactly what it was supposed to do August 24, but ETF investors freaked out, writes Dave Nadig in FactSet. For example during the first hour of the market's open, trading in the Guggenheim S&amp;P 500 Equal Weight ETF (RSP) only happened in 15 to 30 second bursts between halts. Any move of more than 10% within a five minute window triggers a halt, meaning trading halted four times on down moves and six times on up moves.</p> <p>Most investors are "smart enough to treat their ETFs...as long term asset allocation vehicles," says Nadig. The day to day swings can be scary, but most people recognize that it's part of holding such an investment.</p> <p>Investors do need to understand that an ETF isn't to be traded like a stock, says Rosenberg. ETFs seem to trade like stocks, but stocks are driven by supply and demand, where ETFs are tied to the underlying securities, he says.</p> <p>Unlike mutual funds, which just trade once a day at the closing net asset value price, ETFs have to weather the daily trading storms, says Ben Carlson in his blog "A Wealth of Common Sense." "Whenever something goes wrong in the markets (read: losses), people tend to look for someone or something to blame," writes Carlson. It's not the ETFs' fault if an investor put in a sell order and gets stuck with the market's price for the fund. ETF traders should expect this, but long term investors needn't worry. Panics can and will happen on occasion, says Carlson. The trick is just to not be forc</p>
Real Estate Porn: Southampton estate
<p>Looking for an end-of-summer deal? A former Carnegie family summer home is on the market in Southampton for $37.5 million with Sotheby's.</p> <p>The 1890's home holds the Gilded Age charm with modern amenities, over 12,000 square feet.</p> <p>Having a party? No problem. The home has 11 bedrooms, 12 baths, and 11 fireplaces, plus a 2 bedroom, 2 bath apartment complete with a living room and kitchenette.</p> <p>Outside, the grounds hold a swimming pool and tennis court, within walking distance from the ocean.</p> <p>&nbsp;<br /> Photos: Jake Rajs</p>